1993年 Max-Planck-Institut fur Immunbiologie, Dr. Manfred Kopfらにより開発。 D3 ES細胞由来。東大医科研岩倉研でDBA/1に4世代戻し交配 (BRC寄託時)。 129S2/SvPas (D3) IL-4遺伝子欠損マウス。寄生虫感染に対して易感染性。 RBRC05130 true In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 362(6417):245-248 (1993).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Nature, 362(6417):245-248 (1993).<br>研究成果の公表にあたって謝辞の表明を必要とする。 Immunology and Inflammation Research D1;129S2-Il4<tm1Kopf> D1;129S2-Il4<tm1Kopf> D (more than 6 months) 岩倉 洋一郎 Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> D1-Il4 KO Developed by Manfred Kopf, Max-Planck-Institut fur Immunbiologie in 1993. The mice were backcrossed to DBA/1 for at least 4 times by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo. DBA/1JJmsSlc Neomycin resistance gene (E. coli), PolyA signal (SV40), MC1 promoter (HSV) 1993年 Max-Planck-Institut fur Immunbiologie, Dr. Manfred Kopfらにより開発。D3 ES細胞由来。東大医科研岩倉研でDBA/1に4世代戻し交配 (BRC寄託時)。129S2/SvPas (D3) IL-4 knockout mice. Homozygous mutant mice show increased susceptibility to infection of parasites. D(6か月以上) Yoichiro IWAKURA